Nuclei are bound together by the residual strong force (nuclear force). The residual strong force is minor residuum of the strong interaction which binds quarks together to form protons and neutrons. This force is much weaker between neutrons and protons because it is mostly neutralized within them, in the same way that electromagnetic forces between neutral atoms (such as van der Waals forces that act between two inert gas atoms) are much weaker than the electromagnetic forces that hold the parts of the atoms internally together (for example, the forces that hold the electrons in an inert gas atom bound to its nucleus).
The nuclear force is highly attractive at very small distances, and this overwhelms the repulsion between protons which is due to the electromagnetic force, thus allowing nuclei to exist. However, because the residual strong force has a limited range because it decays quickly with distance (see Yukawa potential), only nuclei smaller than a certain size can be completely stable. The largest known completely stable (e.g., stable to alpha, beta, and gamma decay) nucleus is lead-208 which contains a total of 208 nucleons (126 neutrons and 82 protons). Nuclei larger than this maximal size of 208 particles are unstable and (as a trend) become increasingly short-lived with larger size, as the number of neutrons and protons which compose them increases beyond this number. However, bismuth-209 is also stable to beta decay and has the longest half-live to alpha decay of any known isotope, estimated at longer than the age of the universe.
The residual strong force is effective over a very short range (usually only a few fermis; roughly one or two nucleon diameters) and causes an attraction between any pair of nucleons (i.e., between protons and neutrons to form [NP] deuteron, and also between protons and protons, and neutrons and neutrons). It also is effective for the stability of one 3-body nucleon system [PNP], helium-3, while the triton [NPN] is unstable and decays to helium-3.
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